Seasonal fluctuations in vitamin D levels in children with various diseases

The main problem of research on vitamin D sufficiency is the lack an integrated approach, that is, a dynamic assessment 25(OH)D throughout entire period childhood and in different seasons year. This necessary to highlight those specific diseases which priority targeted prevention therapy hypovitaminosis will be indicated, taking into account numerous biological pathophysiological effects metabolites, particular, 25(OH)D, have socially significant clinical consequences. aim study: assess level children with various living Moscow region, season year age. Materials methods. A study was made availability among 1501 regions. Discussion. high frequency severe deficiency found oncological (41.7%), nervous system (12.9) blood (10.9). It shown 25.0% cerebral palsy, 19.4% chronic kidney disease, 16.7% type 1 diabetes mellitus, 15.5% juvenile idiopathic arthritis pronounced 14.8% patients anemia, 10.3% inflammatory bowel 7.9% born prematurely. Conclusion. Severe year-round disorders metabolism were noted suffering from autoimmune (type arthritis), diseases, prematurity, disease.